Histone post‐translational modifications (PTMs) alter the chromatin architecture, generating “open” and “closed” states, and these structural changes can modulate gene expression under specific cellular conditions. While methylation and acetylation are the best‐characterized histone PTMs, citrullination by the protein arginine deiminases (PADs) represents another important player in this process. In addition to “fine tuning” chromatin structure at specific loci, histone citrullination can also promote rapid global chromatin decondensation during the formation of extracellular traps (ETs) in immune cells. Recent studies now show (...) that PAD4‐mediated citrullination of histone H1 at promoter elements can also promote localized chromatin decondensation in stem cells, thus regulating the pluripotent state. These observations suggest that PAD‐mediated histone deimination profoundly affects chromatin structure, possibly above and beyond that of other PTMs. Additionally, these recent findings further enhance our understanding of PAD biology and the important contributions that these enzymes play in development, health, and disease. (shrink)

1 Evidence-based policy requires researchers to provide the answers to ecological questions that are of interest to policy makers. To find out what those questions are in the UK, representatives from 28 organizations involved in policy, together with scientists from 10 academic institutions, were asked to generate a list of questions from their organizations. 2 During a 2-day workshop the initial list of 1003 questions generated from consulting at least 654 policy makers and academics was used as a basis for (...) generating a short list of 100 questions of significant policy relevance. Short-listing was decided on the basis of the preferences of the representatives from the policy-led organizations. 3 The areas covered included most major issues of environmental concern in the UK, including agriculture, marine fisheries, climate change, ecosystem function and land management. 4 The most striking outcome was the preference for general questions rather than narrow ones. The reason is that policy is driven by broad issues rather than specific ones. In contrast, scientists are frequently best equipped to answer specific questions. This means that it may be necessary to extract the underpinning specific question before researchers can proceed. 5 Synthesis and applications. Greater communication between policy makers and scientists is required in order to ensure that applied ecologists are dealing with issues in a way that can feed into policy. It is particularly important that applied ecologists emphasize the generic value of their work wherever possible. (shrink)

What kind of knowledge is medical knowledge? Can medicine be explained scientifically? Is disease a scientific concept, or do explanations of disease depend on values? What is ‘evidence-based’ medicine? Are advances in neuroscience bringing us closer to a scientific understanding of the mind? The nature of medicine raises fundamental questions about explanation, causation, knowledge and ontology – questions that are central to philosophy as well as medicine. In this book Paul R. Thompson and Ross E. G. Upshur introduce (...) the fundamental issues in philosophy of medicine for those coming to the subject for the first time. They introduce and explain the following key topics: Understanding the physician-patient relationship: the phenomenology of the medical encounter. Models and theories in biology and medicine: what role do theories play in medicine? Are they similar to scientific theories? Randomised controlled trials: can scientific experiments be replicated in clinical medicine? What are the philosophical criticisms levelled at RCTs? The concept of evidence in medical research: what do we mean by ‘Evidence-based medicine?’ Should all medicine be based on evidence? Causation in medicine What do advances in neuroscience reveal about the relationship between mind and body? Defining health and disease: are explanations of disease objective or do they depend on values? Evolutionary medicine: what is the role of evolutionary biology in understanding medicine? Is it relevant? Extensive use of empirical examples and case studies is made throughout the book. These include debates about smoking and cancer, the use of placebos in randomised controlled trials and controversies about research into the causes of HIV and autism. This is an indispendable introduction to those teaching philosophy of medicine and philosophy of science. (shrink)

Humans have been modifying plants and animals for millennia. The dawn of molecular genetics, however, has kindled intense public scrutiny and controversy. Crops, and the food products which include them, have dominated molecular modification in agriculture. Organisations have made unsubstantiated claims and scare mongering is common. In this textbook Paul Thompson presents a clear account of the significant issues - identifying harms and benefits, analysing and managing risk - which lie beneath the cacophony of public controversy. His comprehensive (...) analysis looks especially at genetically modified organisms, and includes an explanation of the scientific background, an analysis of ideological objections, a discussion of legal and ethical concerns, a suggested alternative - organic agriculture - and an examination of the controversy's impact on sub-Saharan African countries. His book will be of interest to students and other readers in philosophy, biology, biotechnology and public policy. (shrink)

Evolution - both the fact that it occurred and the theory describing the mechanisms by which it occurred - is an intrinsic and central component in modern biology. Theodosius Dobzhansky captures this well in the much-quoted title of his 1973 paper 'Nothing in biology makes sense except in the light of evolution'. The correctness of this assertion is even more obvious today: philosophers of biology and biologists agree that the fact of evolution is undeniable and that the theory of evolution (...) explains that fact. Such a theory has far-reaching implications. In this volume, eleven distinguished scholars address the conceptual, metaphysical and epistemological richness of the theory and its ethical and religious impact, exploring topics including DNA barcoding, three grand challenges of human evolution, functionalism, historicity, design, evolution and development, and religion and secular humanism. The volume will be of great interest to those studying philosophy of biology and evolutionary biology. (shrink)

Rolf Gruner has argued that natural selection plus time does not entail, and hence does not explain, evolution. This according to Gruner is the result of the undeniable fact that evolution involves an increase in the complexity of organisms:Since increase in complexity is part of the concept of evolution, evolution is not explained by the theory of natural selection. The Darwinian or Neo-Darwinian affirms the reality of evolution and seems to believe that it can be accounted for in terms of (...) natural selection. But it could be accounted for in this way only if the assumption were justified that generally the more complex organism is better adapted to its environment, and thus stands a better chance to survive and breed, than the less complex organism. And this assumption is not justified. “The more complex, the better adapted” will not do even as a rule of thumb, as most biologists today will be prepared to admit. (shrink)

Recent interest in the evolution of the social contract is extended by providing a throughly naturalistic, evolutionary account of the biological underpinnings of a social contract theory of morality. This social contract theory of morality provides an evolutionary justification of the primacy of a moral principle of maximisation of the opportunities for evolutionary reproductive success, where maximising opportunities does not entail an obligation on individuals to choose to maximise their ERS. From that primary principle, the moral principles of inclusion, individual (...) sovereignty and equality can be derived. The implications of these principles, within contractevolism, are explored through an examination of patriarchy, individual sovereignty and copulatory choices, and overpopulation and extinction. Contractevolism is grounded in evolutionary dynamics that resulted in humans and human societies. The most important behavioural consequences of evolution to contractevolism are reciprocity, cooperation, empathy, and the most important cognitive consequences are reason and behavioural modification. (shrink)

Among the numerous criticisms of sociobiology is the criticism that it is not genuine science. This paper defends sociobiology against this criticism. There are three aspects to the defense. First, it is argued that the testability criterion of pseudoscience is generally problematic as a criterion and that even if accepted it fails to mark sociobiology as a pseudoscience. Second, it is argued that Thagard's more comprehensive and sophisticated criterion of pseudoscience fails to mark sociobiology as a pseudoscience. Third, a positive (...) case for accepting sociobiology as genuine science is presented. (shrink)

Medical explanations of socially maladaptive behaviors most often involve an appeal to neuro-physiological models. One consequence of the appeal to such models is a lack of attention to the social character of the behaviors. It is, I argue, the social character of the behaviors that, even accepting a neuro-physiological etiology, makes classification and, hence, explanation of these disorders controversial and suspect. At the heart of the problem is the difficulty, resulting from the social aspects of the disorder, in fulfilling the (...) logical conditions of the analogical arguments employed in the explanations. The theoretical points of the paper are illustrated by a discussion of hyperactivity. CiteULike Connotea Del.icio.us What's this? (shrink)

Peer review is a widely accepted instrument for raising the quality of science. Peer review limits the enormous unstructured influx of information and the sheer amount of dubious data, which in its absence would plunge science into chaos. In particular, peer review offers the benefit of eliminating papers that suffer from poor craftsmanship or methodological shortcomings, especially in the experimental sciences. However, we believe that peer review is not always appropriate for the evaluation of controversial hypothetical science. We argue that (...) the process of peer review can be prone to bias towards ideas that affirm the prior convictions of reviewers and against innovation and radical new ideas. Innovative hypotheses are thus highly vulnerable to being “filtered out” or made to accord with conventional wisdom by the peer review process. Consequently, having introduced peer review, the Elsevier journal Medical Hypotheses may be unable to continue its tradition as a radical journal allowing discussion of improbable or unconventional ideas. Hence we conclude by asking the publisher to consider re-introducing the system of editorial review to Medical Hypotheses. (shrink)

An environmental, climate mitigation rationale for research and development on liquid transportation fuels derived from plants emerged among many scientists and engineers during the last decade. However, between 2006 and 2010, this climate ethic for pursuing biofuel became politically entangled and conceptually confused with rationales for encouraging greater use of plant-based ethanol that were both unconnected to climate ethics and potentially in conflict with the value-commitments providing a mitigation-oriented reason to promote and develop new and expanded sources of biofuel. I (...) argue that the conceptual construct of technological trajectories provides a fecund approach to the ethical evaluation of R&D strategies in the case of plant-based liquid transportation fuels. The idea of a trajectory has a current use in the literature of science studies and aptly summarizes a number of themes that are critical to the evaluation of tools and techniques whose future shape, design, applications and potential consequences are necessarily somewhat speculative. In the case of biofuels, it is the imagined future trajectory that provides the basis for resistance to an emerging technology, rather than the present-day technical capabilities and the unexpected consequences of biofuel development. (shrink)

This book explores historical and current discussions of the relevance of evolutionary theory to ethics. The historical section conveys the intellectual struggle that took place within the framework of Darwinism from its inception up to the work of G. C. Williams, W. D. Hamilton, R. D. Alexander, A. L. Trivers, E. O. Wilson, R. Dawkins, and others. The contemporary section discusses ethics within the framework of evolutionary theory as enriched by the works of biologists such as those mentioned above. The (...) issue of whether ethical practice and ethical theory can be grounded in the theory of evolution has taken a new and significant direction within the context of sociobiology and is proving to be a challenge to previous thinking. This book conveys that challenge. (shrink)

Scrutiny (1932-1953) was one of the most important critical reviews of the last century. Its editors and contributors included F. R. Leavis, Q. D. Leavis, Denys Thompson, L. C. Knights, D. W. Harding, W. H. Mellers, H. A. Mason, among others. In recasting Scrutiny’s critique of mass culture by way of Alisdair MacIntyre’s After Virtue (1981), I hope to show that the Scrutiny project not only dramatizes the conflicts internal to what MacIntyre calls emotivist culture, but provides a new (...) way of looking at the group’s relation to the culture industry, its purported elitism, and its deep ties with a communitarian rather than socialist politics. (shrink)

To all appearances, the basic building blocks of reality tend to keep existing unless something intervenes to destroy them. In other words, basic things seem to have existential inertia. But why might this be? This paper considers a number of arguments for and against existential inertia. It discusses arguments inspired by Aquinas, Descartes, and Spinoza, as well as considerations deriving from Occam’s Razor, entropy, and certain views about the nature of time and change.

"Evidence of a flight from reason is as old as human record-keeping: the fact of it certainly goes back an even longer way. Flight from science specifically, among the forms of rational inquiry, goes back as far as science itself... But rejection of reason is now a pattern to be found in most branches of scholarship and in all the learned professions."--from the introduction In the widely acclaimed Higher Superstition: The Academic Left and Its Quarrels with Science, Paul R. (...) Gross and Norman Levitt offered a spirited response to the "science bashers," raising serious questions about the growing criticism of scientific practice from humanists and social scientists on the academic left. Now, in The Flight from Science and Reason, Gross and Levitt are joined by Martin W. Lewis to bring together a diverse and distinguished group of scholars, scientists, and experts to engage these questions from a wide variety of perspectives. The authors take on critics of science whose views range from moderate to extreme, from social constructivists to deconstructionists, from creationists and feminists to Afro-centrists. They discuss the rise of "alternative medicine" and radical environmentalism (here skewered as "ecosentimentalism"). They explain why the "uncertainty principle" does not work as a metaphor for ambiguity, and why "chaos theory" cannot be invoked without an understanding of mathematics. Throughout, they grapple with the paradox inherent in arguing with opponents who contend that reason itself, and thus logic, is suspect. Distributed for the New York Academy of Sciences. (shrink)

Dimensions of character are often overlooked in professional practice at the expense of the development of technical competence and operational efficiency. Drawing on philosophical accounts of virtue ethics and positive psychology, the present work attempts to elevate the role of ‘good’ character in the professional domain. A ‘good’ professional is ideally one that exemplifies dimensions of character informed by sound judgement. A total of 2340 professionals, from five discrete professions, were profiled based on their valuation of qualities pertaining to character (...) and judgement. Profile differences were subsequently examined in the self-reported experience of professional purpose towards a wider societal ‘good’. Analysis of covariance, controlling for stage of career, revealed that professionals valuing character reported higher professional purpose than those overweighting the importance of judgement or valuing neither character nor judgement, F = 7.92, p <.001. No differences were found between the two groups valuing character, irrespective of whether judgement was valued simultaneously. This profiling analysis of entry-level and in-service professionals, based on their holistic character composition, paves the way for fresh philosophical discussion regarding what constitutes a ‘good’ professional and the interplay between character and judgement. The empirical findings may be of substantive value in helping to recognise how the dimensions of character and judgement may impact upon practitioners’ professional purpose. (shrink)

In this book Paul Hinlicky suggests that to the detriment of the church as a whole Martin Luthers legacy did not unfold as he himself would have hoped or ...

ABSTRACTI argue that, according to just war theory, those who work as administrative personnel in the private military industry can be permissibly harmed while at work by enemy combatants. That is, for better or worse, a just war theorist should consider all those who work as administrative personnel in the private military industry as either: individuals who may be permissibly restrained with lethal force while at work; or individuals who may be harmed by permissible attacks against their workplace. In doing (...) so, I also provide some critical analysis of the relevant just war concepts. (shrink)

H. L. A. Hart famously claimed that part of the appeal of natural law “doctrine” is the “independence” of natural law from divine and human authority. God, according to Hart, is not necessary to natural law. By way of contrast, J. Budziszewski argues that natural law really is law and that law qua law requires an enactor. Moreover, the only plausible candidate for the enactor of natural law as law is the author of nature—that is, God. In this essay I (...) argue that Budziszewski is right and Hart wrong. Law imposes obligations upon those under it, and obligations qua obligation are categorical rather than hypothetical imperatives. Categorical imperatives, in turn, require prescription. Consequently, prescription is necessary to any intelligible account of moral obligation. And prescription, finally, requires an authoritative prescriber. (shrink)

In Pagans & Christians in the City, Steven D. Smith argues that in contrast to ancient Rome, ancient Christianity, following Judaism, located the sacred outside the world, desacralizing the cosmos and everything in it—including the political order. It thereby introduced a political dualism and potentially contending allegiances. Although Smith’s argument is right so far as it goes, it underplays the role of Christianity’s immanent dimension in subverting the Roman empire and the sacral pattern of antiquity. This division of authority not (...) only undermined the Roman empire and antique sacral political order more generally—it also subverts the modern state, which, in the work of Hobbes and Rousseau, sought to remarry what Western Christianity divorced. (shrink)

Many scholars view political contractarianism as a distinctly modern account of the foundations of political order. Ideas such as popular sovereignty, the right of revolution, the necessity of the consent of the governed for rightful political authority, natural equality, and a pre-civil state of nature embody the modern rupture with classical political philosophy and traditional Christian theology. At the headwaters of this modern revolution stands Thomas Hobbes. Since the American founders subscribed to the social contract theory, they are often said (...) to reject classical political philosophy and traditional Christian political theology as well. In America on Trial, Robert Reilly rejects the usual argument. He maintains that the building blocks of the American founding originate in medieval Christian political theology. In this essay, I argue that a morally and metaphysically realist contractarian tradition—one that affirms natural equality, the authority of the society over government, the necessity of consent for legitimate government, the right to resist tyrannical rulers, and the idea of a pre-civil state of nature—predates Hobbes and also that the voluntarist contractarian tradition inaugurated by Hobbes is self-referentially incoherent. A coherent political contractarianism logicially depends on the sort of metaphysics and moral ontology Hobbes rejects. (shrink)

This article explores the notion of the Web-extended mind, which is the idea that the technological and informational elements of the Web can sometimes serve as part of the mechanistic substrate that realizes human mental states and processes. It is argued that while current forms of the Web may not be particularly suited to the realization of Web-extended minds, new forms of user interaction technology as well as new approaches to information representation do provide promising new opportunities for Web-based forms (...) of cognitive extension. In addition, it is suggested that extended cognitive systems often rely on the emergence of social practices and conventions that shape how a technology is used. Web-extended minds may thus depend on forms of socio-technical co-evolution in which social forces and factors play just as important a role as do the processes of technology design and development. (shrink)

There have been a number of attempts to apply mechanism-related concepts to the notion of extended cognition. Such accounts appeal to the idea that extended cognitive routines are realized by mechanisms that transcend some salient border or boundary. The present paper describes some of the challenges confronting the effort to develop a mechanistic account of extended cognition. In particular, it describes five problems that must be resolved if we are to make sense of the idea that extended cognition can be (...) understood via an appeal to extended mechanisms. These problems are intended to guide the philosophical effort to develop a mechanistic account of extended cognition. (shrink)

Mandevillian intelligence is a specific form of collective intelligence in which individual cognitive vices are seen to play a positive functional role in yielding collective forms of cognitive success. The present paper introduces the concept of mandevillian intelligence and reviews a number of strands of empirical research that help to shed light on the phenomenon. The paper also attempts to highlight the value of the concept of mandevillian intelligence from a philosophical, scientific and engineering perspective. Inasmuch as we accept the (...) notion of mandevillian intelligence, then it seems that the cognitive and epistemic value of a specific social or technological intervention will vary according to whether our attention is focused at the individual or collective level of analysis. This has a number of important implications for how we think about the design and evaluation of collective cognitive systems. For example, the notion of mandevillian intelligence forces us to take seriously the idea that the exploitation of individual cognitive shortcomings could, in some situations, provide a productive route to collective forms of cognitive and epistemic success. (shrink)

Using astrology as a case study, this paper attempts to establish a criterion for demarcating science from pseudoscience. Numerous reasons for considering astrology to be a pseudoscience are evaluated and rejected; verifiability and falsifiability are briefly discussed. A theory is said to be pseudoscientific if and only if (1) it has been less progressive than alternative theories over a long period of time, and faces many unsolved problems, but (2) the community of practitioners makes little attempt to develop the theory (...) towards solutions of the problems, shows no concern for attempts to evaluate the theory in relation to others, and is selective in considering confirmations and disconfirmations. This criterion has the interesting consequence that a theory can be scientific at one time but pseudoscientific at another. (shrink)

This study investigates how patterns of media use and exposure to media messages are related to attitudes about artificial intelligence (AI) image generators. In doing so, it builds on theoretical accounts of media framing and public opinion about science and technology topics, including AI. The analyses draw on data from a survey of the US public (N = 1,035) that included an experimental manipulation of exposure to tweets framing AI image generators in terms of real art, artists’ concerns, artists’ outrage, (...) or competing interpretations. The results show that technology news use and science fiction viewing predicted support for AI art but also predicted belief that AI image generators will take jobs and steal art styles from human artists. In addition, the experimental results demonstrate that exposure to specific media messages can influence these responses. The findings carry implications for understanding the future adoption, use, and regulation of AI image generators. (shrink)

The U.S. Constitution provides a framework for our laws, but what does it have to say about morality? Paul DeHart ferrets out that document’s implicit moral assumptions as he revisits the notion that constitutions are more than merely practical institutional arrangements. In _Uncovering the Constitution’s Moral Design_, he seeks to reveal, elaborate, and then evaluate the Constitution’s normative framework to determine whether it is philosophically sound—and whether it makes moral assumptions that correspond to reality. Rejecting the standard approach of (...) the intellectual historian, DeHart for the first time in constitutional theory applies the method of inference to the best explanation to ascertaining our Constitution’s moral meaning. He distinguishes the Constitution’s intention from the subjective intentions of the framers, teasing out presuppositions that the document makes about the nature of sovereignty, the common good, natural law, and natural rights. He then argues that the Constitution constrains popular sovereignty in a way that entails a real common good, transcendent of human willing and promotive of human well-being, but he points out that while the Constitution presupposes a real common good, it also implies a natural law that prescribes the common good. In critiquing previous attempts at describing and evaluating the Constitution’s normative framework, DeHart demonstrates that the Constitution’s moral framework corresponds largely to classical moral theory. He challenges the logical coherency of modern moral philosophy, normative positivism, and other theories that the Constitution has been argued to embody and offers a groundbreaking methodology that can be applied to uncovering the normative framework of other constitutions as well. This cogently argued study shows that the Constitution presupposes a natural law to which human law must conform, and it takes a major step in resolving current debates over the Constitution’s normative framework while remaining detached from the social issues that divide today’s political arena. _Uncovering the Constitution’s Moral Design_ is an original approach to the Constitution that marks a significant contribution to understanding the moral underpinnings of our form of government. (shrink)

We argue that mereological essentialism for events is independent of mereological essentialism for objects, and that the philosophical fallout of embracing mereological essentialism for events is minimal. We first outline what we should consider to be the parts of events, and then highlight why one would naturally be inclined to think that the object-question and the event-question are linked. Then, we argue that they are not. We also diagnose why this is the case and emphasize the upshot. In particular, we (...) argue that the way we evaluate modal claims which concern events differs from the way we evaluate modal claims which concern objects. Ultimately, then, to our title question we say: the answer does not matter as much as you might think. (shrink)